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Xiaflex Reviews - What Is It?

Author: Eric Lander Eric Lander

WARNING: DO NOT BUY Xiaflex Until You Read This Review!
Is it a Scam? Does It Really Work? Check Ingredients, Side Effects and More!

Xiaflex is a FDA-approved nonsurgical prescription remedy for the treatment of patients who suffer from Dupuytren's contracture (a patient feels a "cord"), Peyronie's disease (a curve in a penis not greater than 30 degrees or a plaque in the male organ). This medication can also be used to treat other health conditions caused by a certain protein (collagen) in the sufferer's body. Let me remind that collagen is a strong and tough substance that can be found in the cords and knots of the hand in case of having Dupuytren's contracture or penis plaques (Peyronie's disease). Collagenase is an enzyme that tends to break down the collagen in these cords, knots or plaques.

The manufacturer behind Xiaflex is not very popular in the country. According to the official website, it is a registered trademark of Endo International plc. The official website contains completely no information on the contents of the product, however, it depicts all possible side effects and adverse reactions which can be associated with the use of the product. To contact the company you will need to fill in a special form on their official website. However, it should not be used for reporting adverse reactions.

Ingredients of Xiaflex - Does It Really Work? Is It a Scam?

Another name of this treatment is Collagenase clostridium histolyticum injection. Before starting to use Xiaflex, you are highly recommended to read the Medication Guide given by your healthcare professional. If you have any concerns of questions, ask your doctor. For the treatment of Dupuytren's contracture, the medication needs to be injected into the tissue knot (cord) of your hand. The procedure should be done by your healthcare provider or doctor only. The specialist will then wrap your hand into soft gauze. Try to move your hand minimally and keep it elevated until going to bed. Do not curl, straighten, or move the injected finger until you are asked about this by your doctor. If you feel tingling, numbness, or Any other unpleasant feeling in your hand during or after the procedure, inform your doctor.


You are advised to come back to your doctor's office within several days after the injection. Your hand must be checked by the doctor who will try to straighten the finger and apply a splint which should be worn every night for up to 4 months. You will be advised to do certain finger exercises and avoid doing strenuous activity with the affected hand. If you still fail to straighten your finger after a month of using Xiaflex, inform your doctor about it who may give you another injection. You cannot have more than three injections, each a month apart.

If you have Peyronie's disease, this medication is injected into the plaque in your penis by your doctor. The specialist will inform you how often the procedures will take place. Each treatment cycle usually contains two injections a few days apart and a modeling procedure several days after the second injection. It is prohibited to have a sexual intercourse for at least two weeks after the last injection. Some men may need four treatment cycles. They are about six weeks apart. You should follow your doctor's recommendations on straightening the penis.

The manufacturer of Xiaflex gives a number of precautions. The product should not be received by people whose Peyronie's plaque involves urethra, those allergic to collagenase clostridium histolyticum or any other collagenase product. Xiaflex can cause serious side effects which will be discussed in the next section of this review. The product for the treatment of Peyronie's disease can be bought through a restricted program (Risk Evaluation and Mitigation Strategy Program or REMS).

Before receiving the injection, inform your healthcare provider if you have a bleeding problem or any serious medical conditions. Inform your doctor about all the drugs you take, vitamins, or supplements. Xiaflex can cause side effects when used with other drugs, especially those to thin your blood. Let us have a look at possible side effects which can be caused by the product.

Customer Reviews - Does It Have Any Side Effects?

Xiaflex is associated with a number of severe side effects, for example, penile fracture or other injury to the male penis. This kind of injection may lead to the damage of the tubes in the male organ called the corpora. After the treatment, an erection may cause breaking of one of these tubes. This can be very dangerous and requires immediate surgery. Besides, after treatment with this product, your penis blood vessels may also break easily, causing hematomas. You may need a procedure to drain the blood.

Xiaflex can cause ligament damage or tendon rupture in your hand. You may need an urgent surgery to fix the damage. Call your doctor right away if you cannot bend your injected finger after the swelling goes down. Inform your healthcare provider if you get increased pain, tingling, numbness, or tears in the skin. You may also have hypersensitivity reactions, including anaphylaxis. The matter is that Xiaflex contains foreign proteins which can cause the symptoms of an allergic reaction including swollen face, hives, breathing trouble, dizziness, low blood pressure, chest pain, or fainting.

People getting the injection have a higher risk of bleeding or bruising at the injection site. That is why the product can be dangerous for people who have problems with blood clotting. However, the most common Xiaflex side effects include: bruising or bleeding at the injection site, swelling of the injection site or the hand, tenderness or pain of the injection site or the hand, itching, swelling of the lymph nodes (glands) in the elbow or armpit, breaks in the skin, pain in the armpit, redness or warmth of the skin. Let us see what people are saying about the treatment with this drug.

"For me, the treatment with XiaFlex was a waste of time. They failed to deaden my hand before the procedure, so I felt pain. In general, I had four treatments but these didn't help me to reduce my pain level, straighten my fingers, or remove the lumps from my tendons."

"I had Xiaflex treatment on my right hand to fix my 45-degree contracture. I felt a lot of discomfort, pain shots, soreness and swelling within five days after the injection. I am still unable to move my hand. I need to wear a splint while I sleep. I hope it will bring some result."

"I had a pinky finger. At first I thought it was a cyst but my doctor suggested Xiaflex. The injection was very painful, my hand was completely wrapped. Two days later, I had an extremely painful injection of anesthesia and manipulation. My hand was three times bigger its normal size. Three weeks have already passed but my finger is not totally straight. It is still swollen."

Where To Buy Xiaflex?

Xiaflex is a prescription drug, so you will need a doctor's prescription who will do the procedure for you as well. Xiaflex costs around $3250 per injection. You may need several procedures which makes the treatment extremely expensive. The product isn't available on Amazon, Walmart or GNC.

My Final Summary

I don't think that Xiaflex is a good remedy for Dupuytren's contracture and Peyronie's disease. By looking at people's reviews, we can see that many of them did not achieve the expected results. The procedures are extremely painful and don't guarantee any positive result. At the same time, this treatment is very expensive. I think that you should look for other ways to treat these health conditions.

Affordable Alternative

Many doctors consider that the problem can be well solved by another product known as ProExtender and I completely agree with them. I recommend you reading my review about ProExtender. You'll be pleasantly surprised.


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[2] Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing / M Imielinski, AH Berger, PS Hammerman, B Hernandez, TJ Pugh / Cell 150 (6), 1107-1120 / 2012

Xiaflex | ProstaGenix | ProExtender | Provacyl